Original Publication Date: 1 April, 2014
Publication / Source: Nanomedicine
Authors: Songwei Tan, Tetsuro Sasada, Anna Bershteyn et al
Aim: The authors aimed to investigate whether nanotechnology-based delivery of antigenic peptides is feasible for efficiently inducing anti-tumor cytotoxic T lymphocyte responses through vaccination. Materials & methods: Three different murine melanoma antigens were entrapped in lipid-coated poly(D,L-lactide-co-glycolide) nanoparticles (NPs) by the double emulsion method. Results: The loading efficiency of hydrophilic peptides was greatly improved when lipids were introduced to formulate lipid-coated NPs.