Oncology Central

Mutation profiling and prediction of outcome in acute myeloid leukemia


Acute myeloid leukemia (AML) is a heterogeneous disease characterized by accumulation of somatically acquired genetic alterations in hematopoietic progenitor cells. Cytogenetic analysis has been used for more than three decades and has allowed classifications of AML patients into distinct subsets that differ in biologic and prognostic characteristics [1,2].

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