Original Publication Date: 4 June, 2014
Publication / Source: Immunotherapy
Authors: Kim A Reiss, Patrick M Forde & Julie R Brahmer
Cancer cells employ several mechanisms to evade the immune system of their host, thus escaping immune recognition and elimination. Of particular interest is a cancer cell’s ability to co-opt the immune system’s innate ligands and inhibitory receptors (also known as checkpoints), thus creating an immunosuppressive microenvironment that downregulates T-cell activation and cell signaling.