Oncology Central

Harnessing the power of the immune system via blockade of PD-1 and PD-L1: a promising new anticancer strategy


Cancer cells employ several mechanisms to evade the immune system of their host, thus escaping immune recognition and elimination. Of particular interest is a cancer cell’s ability to co-opt the immune system’s innate ligands and inhibitory receptors (also known as checkpoints), thus creating an immunosuppressive microenvironment that downregulates T-cell activation and cell signaling.

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