Oncology Central

Investigating the metastatic niche in melanoma: a new therapeutic opportunity?


Cutaneous melanoma is endowed with a high metastatic potential, possibly due to the elevated migratory capability of the cells originating the tumor, the melanocytes [1]. The primary metastatic site is the draining lymph nodes and, as in most solid cancers, nodal status is a relevant predictor of patients’ outcome. When the malignancy goes beyond the regional lymph nodes and invades distant tissues, the overall survival of the patients is very short. Indeed, patients succumb to metastatic burden [1].

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