Original Publication Date: 25 May, 2014
Publication / Source: Colorectal Cancer
Authors: Sabela Carballal, Maria Liz Leoz, Leticia Moreira, Teresa Ocaña & Francesc Balaguer
Colorectal cancer (CRC) is one of the most common malignancies and the second-leading cause of cancer death in both sexes in developed countries. Over the last 25 years, highly penetrant monogenic germline mutations that predispose to CRC and other digestive tumors have been identified, accounting for up to 5% of all CRC cases. Identification and characterization of these disorders have allowed modification of their natural history, with a substantial decrease in morbidity and mortality among high-risk patients.