Original Publication Date: 1 February, 2014
Publication / Source: Future Oncology
Authors: Etienne De Braekeleer, Nathalie Douet-Guilbert, Audrey Basinko et al.
In humans, class I homeobox genes (HOX genes) are distributed in four clusters. Upstream regulators include transcriptional activators and members of the CDX family of transcription factors. HOX genes encode proteins and need cofactor interactions, to increase their specificity and selectivity. HOX genes contribute to the organization and regulation of hematopoiesis by controlling the balance between proliferation and differentiation.