Oncology Central

mTOR: a new therapeutic target for pediatric low-grade glioma?


Pediatric low-grade gliomas (PLGG) represent the most frequent primary brain tumors in children. Despite their low growth rates, a subset may progress or cause substantial morbidity when located in critical brain regions where aggressive surgical resections are not possible. Conventional treatments for young children with unresectable PLGG have avoided radiation therapy due to the significant effects of radiation on the developing brain [1].

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