Original Publication Date: 1 March, 2014
Publication / Source: Breast Cancer Management
Authors: Anjali Shukla, Jude Alsarraj & Kent Hunter
Metastasis is a complex phenotype that is not discrete, is polygenic, varies in range over the entire population and follows non-Mendelian inheritance. Recent evidence indicates that inherited susceptibility affects not only the development of the primary tumor, but is also an important factor in progression and metastasis. Since metastasis accounts for the majority of breast cancer deaths, identification and understanding of the genetic modifiers of metastasis underlies success of personalized therapy.