Original Publication Date: 1 March, 2014
Publication / Source: Future Oncology
Authors: Guangliang Li & Lisong Teng
Evaluation of Potter NE, Ermini L, Papaemmanuil E et al. Single-cell mutational profiling and clonal phylogeny in cancer. Genome Res. 23(12), 2115–2125 (2013).
A major challenge in cancer therapy lies in its complexity and heterogeneity, with increasing recognition of many tumor subtypes that have different biological characteristics and responses to therapies. To effectively address this challenge, personalized medicine has been the ‘vogue’ currently. Dissecting the detailed clonal architecture of cancer by cancer genomics, which holds the promise of personalized medicine, has significant clinical implications.