Oncology Central

Role of cyclin polymorphisms in predicting outcome of 5-fluorouracil-based chemotherapy in colorectal cancer: one piece in a complex puzzle

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The last 20 years has witnessed a significant increase in our knowledge and understanding of the complex pathways and molecular signals that are deregulated in colorectal cancer (CRC). This remarkable progress has been made possible through numerous technological advances and extensive collaborative efforts within the pharmaceutical, clinical and research communities and has led to the identification of promising new drug targets and the development of new drugs.

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