Original Publication Date: 26 March, 2014
Publication / Source: Nanomedicine
Authors: Sourabh Shukla, Amy M Wen, Nadia R Ayat, Ulrich Commandeur, Ramamurthy Gopalkrishnan, Ann-Marie Broome, Kristen W Lozada, Ruth A Keri & Nicole F Steinmetz
Aim: Nanoparticles based on plant viruses are emerging biomaterials for medical applications such as drug delivery and imaging. Their regular structures can undergo genetic and chemical modifications to carry large payloads of cargos, as well as targeting ligands. Of several such platforms under development, only few have been characterized in vivo. We recently introduced the filamentous plant virus, potato virus X (PVX), as a new platform. PVX presents with a unique nanoarchitecture and is difficult to synthesize chemically.