Original Publication Date: 7 March, 2014
Publication / Source: Future Oncology
Authors: Georgios D Lianos & Dimitrios H Roukos
Almost six decades have been spent by researchers and clinicians, after the DNA double helix discovery, on the simple transcription concept of a single gene–phenotype linear approach. All currently available drugs, including targeted agents, against a single genetic abnormality , are based on this idea established by Crick in 1958 . However, the transcriptional process is far more complicated , with recent evidence for transcriptional circuitry driving genes and cell function.