Original Publication Date: 6 March, 2014
Publication / Source: Nanomedicine
Authors: Jie Gao, Yu Xia, Huaiwen Chen, Yongsheng Yu, Jinjing Song, Wei Li, Weizhu Qian, Hao Wang, Jianxin Dai & Yajun Guo
Aims: The aim of this study was to obtain adriamycin-loaded polymer–lipid hybrid nanoparticles conjugated with anti-EGF receptor antibody (PLNP-Mal-EGFR) for hepatocellular carcinoma (HCC) chemotherapy. Materials & methods: The nanoparticles were characterized by dynamic light scattering and fluorescence spectroscopy. The in vitro and in vivo distribution and anti-tumor activity of the nanoparticles were evaluated.