Original Publication Date: 1 March, 2014
Publication / Source: Women's Health
Authors: Virginia Espina, John Wysolmerski, Kirsten Edmiston & Lance A Liotta
Preinvasive breast carcinoma cells that proliferate and accumulate within the nonvascular, closed intraductal niche are under severe hypoxic and metabolic stress. Understanding the survival mechanisms used by these cells has revealed therapeutic strategies for killing preinvasive neoplasms. We have found that autophagy (‘self-eating’) is a major survival strategy used by preinvasive carcinoma and breast cancer stem-like cells.