Original Publication Date: 15 February, 2014
Publication / Source: Breast Cancer Management
Authors: Leen Sas, Peter B Vermeulen, Peter van Dam, Luc Y Dirix, Filip Lardon & Steven J Van Laere
Inflammatory breast cancer (IBC) is a very aggressive form of breast cancer with a high mortality rate. Most patients have lymph node metastasis at the time of diagnosis and 30% of patients already have metastases in distant organs. IBC is normally treated with multimodality therapy. Endocrine therapy is administered in cases of ER-positive tumors. Nevertheless, IBC has a high HOXB13:Il17RB ratio, predicting a poor response to tamoxifen treatment.