Original Publication Date: 12 February, 2014
Publication / Source: Nanomedicine
Authors: Cuiping Yang, Fei Xiong, Jing Wang, Jun Dou, Junsong Chen, Dengyu Chen, Yu Zhang, Shouhua Luo & Ning Gu
Aim: To investigate the effects of anti-ABCG2 monoclonal antibodies (mAbs) in combination with paclitaxel iron oxide nanoparticles (PTX-NPs) on CD138–CD34– multiple myeloma (MM) cancer stem cells (CSCs) in JJN3 cells. Materials & methods: PTX-NPs were prepared using the hydrophobic interaction of the polyoxypropylene chain and oleic acid on the surface of iron oxide NPs and were targeted to the ABCG2 transporter overexpressing MM CSCs with mAbs.