Original Publication Date: 10 February, 2014
Publication / Source: Breast Cancer Management
Authors: Debora de Melo Gagliato & Ana M Gonzalez-Angulo
Breast cancer (BC) is a highly prevalent disease. Worldwide, it is the most common cancer diagnosed and the leading cause of cancer death in women, making this disease a very important focus of interest and research. There is great heterogeneity in clinical outcomes among women diagnosed with BC, possibly indicating that biological heterogeneity is a major factor interfering with tumor development and progression. Presently, it is known that specific genetic expression patterns divide BC into distinct molecular subtypes. In fact, a better understanding of molecular profiles in BC and more advances in biological technology has divided each BC subtype further into additional subcategories.