Oncology Central

Urinary aHGF, IGFBP3 and OPN as diagnostic and prognostic biomarkers for prostate cancer

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Aim: Serum PSA screening for prostate cancer (PCa) is controversial. Here, we identify three urinary biomarkers – aHGF, IGFBP3 and OPN – for PCa screening and prognostication. Methods: Urinary aHGF, OPN and IGFBP3 from healthy men (n = 19) and men with localized (n = 65) and metastatic (n = 36) PCa were quantified via ELISA. Mann–Whitney nonparametric t-test and the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) analyses were used to analyze associations.

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