Original Publication Date: 1 February, 2014
Publication / Source: Biomarkers in Medicine
Authors: Alisa J Prager, Cynthia R Peng, Elena Lita et al
Aim: Serum PSA screening for prostate cancer (PCa) is controversial. Here, we identify three urinary biomarkers – aHGF, IGFBP3 and OPN – for PCa screening and prognostication. Methods: Urinary aHGF, OPN and IGFBP3 from healthy men (n = 19) and men with localized (n = 65) and metastatic (n = 36) PCa were quantified via ELISA. Mann–Whitney nonparametric t-test and the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) analyses were used to analyze associations.