Original Publication Date: 28 January, 2014
Publication / Source: Nanomedicine
Authors: Kevin C Weng, Rintaro Hashizume, Charles O Noble et al
Aim: The aim of this work is to evaluate combining targeting strategy and convection-enhanced delivery in brain tumor models by imaging quantum dot–immunoliposome hybrid nanoparticles. Materials & methods: An EGF receptor-targeted, quantum dot–immunoliposome hybrid nanoparticle (QD-IL) was synthesized. In vitro uptake was measured by flow cytometry and intracellular localization was imaged by confocal microscopy. In the in vivo study, QD-ILs were delivered to intracranial xenografts via convection-enhanced delivery and fluorescence was monitored noninvasively in real-time.