Original Publication Date: 26 January, 2014
Publication / Source: Biomarkers in Medicine
Authors: Marianne Schmid, Jens Hansen, Micheal Rink, Margit Fisch & Felix Chun
A main limitation of early prostate cancer (PCa) detection due to elevated PSA levels is caused by the low specificity of PSA, which is associated with a high proportion of men detected with nonmalignant findings at first or subsequent prostate biopsy (PBX). Multivariate prediction models, such as nomograms, have been developed, providing a more accurate method to prospectively determine the risk of a positive PBX. Combining established clinical risk factors with novel diagnostic markers of PCa appears promising to further improve predictive accuracy estimates.