Oncology Central

Is there an association between type II endometrial carcinomas and breast cancers? A critical appraisal


Over 47,000 endometrial carcinomas are diagnosed annually in the USA, making them the most prevalent gynecologic tract malignancy [1]. For several decades, endometrial carcinomas have been classified into two broad groups based on epidemiologic, pathologic and clinical factors [2]. In this dualistic model, type I endometrial carcinomas, the prototype that is the endometrioid histotype, constitute the vast majority of endometrial cancers, are associated with hyperestrogenic states, are predominantly uterus-confined at presentation, and are generally associated with favorable patient outcomes [2]. Type II endometrial carcinomas are more heterogeneous and typically display the opposite of the aforementioned features for type I cancers [2].

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