Original Publication Date: 23 January, 2014
Publication / Source: Women's Health
Authors: Oluwole Fadare
Over 47,000 endometrial carcinomas are diagnosed annually in the USA, making them the most prevalent gynecologic tract malignancy . For several decades, endometrial carcinomas have been classified into two broad groups based on epidemiologic, pathologic and clinical factors . In this dualistic model, type I endometrial carcinomas, the prototype that is the endometrioid histotype, constitute the vast majority of endometrial cancers, are associated with hyperestrogenic states, are predominantly uterus-confined at presentation, and are generally associated with favorable patient outcomes . Type II endometrial carcinomas are more heterogeneous and typically display the opposite of the aforementioned features for type I cancers .