Original Publication Date: 14 January, 2014
Publication / Source: Lung Cancer Management
Authors: Orna Barash, Ulrike Tisch & Hossam Haick
Detecting exhaled volatile organic compounds (VOCs) that are associated with lung cancer (LC) has realistic potential for becoming an integral part of population-based LC screening and monitoring in the near future. Here, we review the main three approaches for profiling VOCs in LC patients and their advantages and pitfalls: first, mass spectrometry techniques for the identification and/or quantification of a wide variety of separate breath VOCs; second, canines that are trained to sniff out LC; and third, cross-reactive chemical sensors in combination with statistical methods for identifying disease-specific patterns.