Oncology Central

Incidence and prognostic value of recurrent chromosomal abnormalities in elderly patients with multiple myeloma


Evaluation of: Avet-Loiseau H, Hulin C, Campion L et al. Chromosomal abnormalities are major prognostic factors in elderly patients with multiple myeloma: the Intergroupe Francophone du Myelome experience. J. Clin. Oncol. 31(22), 2806–2809 (2013). Chromosomal abnormalities are well-established biomarkers used in the subclassification and risk stratification of multiple myeloma patients. Patients with t(4;14)(p16;q32) and deletion 17p13 are considered to have a poor prognosis, and do not respond to any of the available therapies. However, most studies of chromosomal abnormalities incidence and risk stratification have been performed in patients younger than 66 years of age; therefore we have very limited data on the elderly population.

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