Original Publication Date: 29 December, 2013
Publication / Source: Breast Cancer Management
Authors: Michael K Leverentz, Ahmet Acar & Keith Brennan
The Notch signaling pathway has been shown to play a pivotal role in the etiology of breast cancer, as it is aberrantly activated in many forms of the disease, and sustained signaling through the pathway is required to maintain the transformed phenotype. These discoveries have resulted in significant interest in targeting the pathway in breast cancer treatment. Over the past decade, several Notch pathway inhibitors have entered the initial stages of clinical trials as monotherapies.