Oncology Central

Cancer stem cells: moving past the controversy

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It has long been recognized that tumors contain cellular heterogeneity and share histological features with developing tissues. These observations have recently been validated with functional assays to confirm the presence of a cancer stem cell (CSC) population in many advanced cancers, including glioblastoma (GBM) [1–4]. Although the CSC hypothesis remains contentious, CSCs have been well established in several advanced cancers, such as leukemia, breast and colon cancer (see the review by Visvader and Lindeman [5]), however, their existence is less clear in other cancers, including lymphoma [6].

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