Oncology Central

Cancer stem cells: moving past the controversy


It has long been recognized that tumors contain cellular heterogeneity and share histological features with developing tissues. These observations have recently been validated with functional assays to confirm the presence of a cancer stem cell (CSC) population in many advanced cancers, including glioblastoma (GBM) [1–4]. Although the CSC hypothesis remains contentious, CSCs have been well established in several advanced cancers, such as leukemia, breast and colon cancer (see the review by Visvader and Lindeman [5]), however, their existence is less clear in other cancers, including lymphoma [6].

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