Original Publication Date: 12 December, 2013
Publication / Source: Future Oncology
Authors: Wilson I Gonsalves, Vinay Gupta, Jacob P Smeltzer, Preet P Singh, Robert R McWilliams & Naseema Gangat
Cancer-associated thrombotic microangiopathy (TMA) is a rare but serious condition seen in patients diagnosed with malignancy. Certain tumor characteristics highlight this entity, such as large tumor burden, adenocarcinoma histology with mucinous features and bone marrow infiltration. Although these tumors may originate from any site, the majority are of stomach, breast or prostate origin. The optimal therapy is unknown but there is evidence that immediate initiation of an effective antineoplastic regimen is important.