Oncology Central

The emerging relevance of heterogeneity of treatment effect in clinical care: a study using stage IV prostate cancer as a model


Aim: Heterogeneity of treatment effect (HTE) occurs when patient factors modify a treatment’s effect on health outcomes due to interactions between these factors and the treatment. This article reviews evidence regarding HTE in stage IV prostate cancer (S4PC). Method: A systematic literature review was conducted in the MEDLINE and PubMed databases. Inclusion criteria required that articles examine the treatment-related impact of HTE factors on survival, adverse events or health-related quality of life in S4PC patients. The quality of evidence was graded good, fair or poor based on Agency for Healthcare Research and Quality guidelines.

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