Original Publication Date: 8 December, 2013
Publication / Source: Journal of Comparative Effectiveness Research
Authors: Nirupama D Mitikiri, Emily S Reese, Arif Hussain, Eberechukwu Onukwugha, Daryl Pritchard, Robert Dubois & C Daniel Mullins
Aim: Heterogeneity of treatment effect (HTE) occurs when patient factors modify a treatment’s effect on health outcomes due to interactions between these factors and the treatment. This article reviews evidence regarding HTE in stage IV prostate cancer (S4PC). Method: A systematic literature review was conducted in the MEDLINE and PubMed databases. Inclusion criteria required that articles examine the treatment-related impact of HTE factors on survival, adverse events or health-related quality of life in S4PC patients. The quality of evidence was graded good, fair or poor based on Agency for Healthcare Research and Quality guidelines.