Oncology Central

Taking radiation out of the equation in primary mediastinal B-cell lymphoma


Primary mediastinal B-cell lymphoma (PMBL) is a subtype of diffuse large B-cell lymphoma (DLBCL) that arises in the thymus [1]. PMBL accounts for up to 10% of cases of DLBCL and predominantly affects females in the third and fourth decade of life. Its clinical presentation is distinct from that of other types of DLBCL and resembles nodular sclerosing Hodgkin lymphoma in that it typically presents with an anterior mediastinal mass that may infiltrate into adjacent structures, such as the lungs and chest wall [1].

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