Original Publication Date: 13 November, 2013
Publication / Source: Colorectal Cancer
Authors: Vincenzo Valentini, Francesco Cellini & Maria Antonietta Gambacorta
Worldwide earlier diagnosis and improvement in treatment modalities gained a huge amelioration of clinical results for locally advanced rectal cancer (i.e., T3, T4 and/or nodal positive clinical presentations) in the last three decades, but still there is urgency for further improvement; moreover, there are some controversies regarding the preferable clinical management. Radiotherapy currently plays a central role in primary treatment [1,2]. In the 1990s, at the beginning of the use of preoperative radiotherapy, its use gained a survival benefit with respect to the use of surgery alone .