Original Publication Date: 3 January, 2013
Publication / Source: Women's Health
Authors: Long Nguyen, Segundo Joel Cardenas-Goicoechea, Pierre Gordon et al
Ovarian cancer is the most lethal gynecological malignancy. However, effective screening strategies have not been established and continue to be elusive. A good screening test must adequately address validity, reliability, yield, cost, acceptance and follow-up services. An ideal screening test for ovarian cancer must have a high sensitivity in order to correctly diagnose all women with the disease and a high specificity to avoid false-positive results. The current screening modalities of bimanual examination, CA-125 and transvaginal ultrasonography together allow us to detect only 30–45% of women with early-stage disease. Recent developments in proteomic and genomic research have identified a number of potential biomarkers.