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0Using big data for quality assessment in oncology

This article describes how current big data resources can be used to assess the six aims for improving healthcare quality dimensions, and provides examples of published studies in oncology.

Brain and neurologic

Does valproic acid affect tumor growth and improve survival in glioblastomas?

Systemic therapies in the treatment of non-small-cell lung cancer brain metastases

Combination immunotherapy shows promising preclinical results in glioblastoma

Breast

Current use of combined HRT could increase the risk of breast cancer almost three fold

Estrogen-deprivation therapy demonstrated to alter mutations in ER-positive breast cancer

Long-term effects of 'chemobrain' following chemotherapy demonstrated in mice

Colorectal

DNA methylation patterns as noninvasive biomarkers and targets of epigenetic therapies in colorectal cancer

Combining curcumin and silymarin could hold promise in colon cancer

Metastatic colorectal cancer: markers to inform treatment selection

Endocrine

The role of epigenetics and long noncoding RNA MIAT in neuroendocrine prostate cancer

Targeting PI3K isoform shows therapeutic promise in pancreatic neuroendocrine tumors

New treatment hopes for patients with inoperable neuroendocrine cancers?

Gastrointestinal

Linking lifestyle factors and esophageal cancer risk – interview with Susannah Brown

Safety and efficacy of regorafenib determined in Phase III liver cancer trial

Current advances in targeted therapies for metastatic gastric cancer: improving patient care

Genitourinary

Metabolism genes may embody marker of response to nivolumab in renal cell carcinoma

Systemic therapy for metastatic bladder cancer in 2016 and beyond

New research could help personalize treatment in early bladder cancer

Gynecologic

Ovarian cancer: SOX2 & SIK2 may represent novel diagnostic marker/therapeutic target

Should older women be vaccinated against human papillomavirus, too?

BRCA1 gene may increase serous endometrial cancer risk

Head and neck

Induction chemotherapy for head and neck cancer: is there still a role?

US FDA grant approval of pembrolizumab for advanced head & neck cancer

Salivary epigenetic biomarkers in head and neck squamous cell carcinomas

Hematologic

Conjugate therapy shows promise in killing acute lymphoblastic leukemia cells

Biomarkers of susceptibility following benzene exposure: influence of genetic polymorphisms on benzene metabolism and health effects

Novel discovery improves profiling of acute myeloid leukemia patients for targeted therapies

Lung

Potential new therapeutic target discovered for adenocarcinomas of the lung

Novel therapeutic target indentified in KRAS-driven lung cancer

Immune checkpoint therapy for non-small-cell lung cancer: an update

Pancreatic

Unique pancreatic cancer cell survival mechanism uncovered

Researchers fight to tackle pancreatic cancer’s resistance to personalized medicine

Developments in miRNA gene signaling pathways in pancreatic cancer

Prostate

Study suggests method to individualize treatment in metastatic prostate cancer

ProCA1.GRPR: a new imaging agent in cancer detection

The role of epigenetics and long noncoding RNA MIAT in neuroendocrine prostate cancer

Rare tumors

Low-dose brachytherapy strategies to treat uveal melanoma: is less more?

Should clinical trials be approached differently for rare cancers?

Novel targets for natural killer/T-cell lymphoma immunotherapy

Skin

Improved survival reported for melanoma patients treated with combination ipilimumab and local therapies

Predictors of tumor-infiltrating lymphocyte efficacy in melanoma

Advanced melanoma patient in remission 5 years after combination immunotherapies